How Can a Threesome Spice Up the Bedroom Experience?

After some time, are your bedroom life becoming boring and blue? Here we are gonna know the ways to spice it up and how can a threesome work.

 

Many people believe that human beings aren’t monogamous by nature. Threesomes are a testament to that. But like every other thing related to human experiences, they work differently for different people.

 

Whether it works for you or not, there’s no use denying that you have, at some point in your life, fantasized about a threesome. In research, it was shown that around 80% of the participants, men, and women alike, fantasized about having a threesome. However, less than half the number reported actually having experienced them.

 

A gap exists between fantasizing about threesomes and actually having them. A number of factors come into play here, including fear, taboos, and insecurities. However, there is only one way of knowing for sure: having a threesome.

 

You can decide whether you want to continue having it or not, but everyone should experience it once in their lives. Here is how threesomes spice up the bedroom experience.

 

It’ll Shake Up Your Routine

 

Well sorry for being Captain Obvious here, but threesomes literally spice up your sex life. A change from the daily, mundane routine that you and your partner have built, particularly if you’ve been in a relationship for long.

 

It’s a chance to do something new and exciting in the background. And it’s a guarantee that things will never go back to being the same again (in a good way)!

 

Explore and Experiment

 

Threesomes give you a chance to explore your sexuality, and your partner’s. if you’re single, it can help you see what kind of relationships you lean more towards. If you’re having a threesome dating as a couple, it’ll not only help you learn new things about yourself but your partner too. You will discover new ways, news positions, and new kinks.

 

For many people, particularly those who have been with their partners from a young age, it’s a chance to explore their sexuality AND experience sex with new people, all the while staying (and strengthening) their relationship with their partners.

 

Once you know yourself and your partner better, you’re bound to have a much more pleasurable bedroom life.

 

Double The Pleasure, Double the Fun

 

Again, stating the obvious. Having sex with one person is plenty of fun on its own. Imagine having it with two people! Even better, imagine having it with two people you’re attracted to. Say you’re a girl and there’s another girl you’re attracted to. But you have a boyfriend. What would be better than getting to have both of them, together?

 

In a threesome, you have to put in the double effort. However, the return is doubled too. You’ll have double the pleasure and definitely much more fun!

 

It Gives You a Good Ego Boost

 

Feeling desired is an instant ego boost for us humans. And being able to provide pleasure to the ones we desire is even a bigger ego boost.

 

What’s better than both of these though? Multiplying it by two. Nothing works your self-esteem more than knowing that you’re desired by not one but two people, and at the same time, you’re able to satisfy not just one but two people.

 

And we all know it. More confidence means better sex anyway!

Four Ways Call Accounting and Reporting Remains Relevant

A telecommunication software or hardware application that provides details regarding the usage of the telephone is called a call accounting system. This system can be used to capture, record, or assign a cost to the telephone usages with the small business as well as large enterprise.

Call reporting and accounting are an important part of the UC (unified communications) brand because it explains about what happened with the telecom interactions of your company. The analytics of both of them explains why it happened and what more can be expected.

Call reporting and accounting provide needy information to optimize your business. In-depth analysis and reporting on internal, incoming and outgoing calls, you can see your telephone activities out and inside. This analysis permits for easy tracking of details of individual departments, locations, and extensions to interact with your call data appropriately to grow your business. It also provides information about necessary changes to increase efficiency and productivity, build revenue and reduce expenses.

Sai accounting provides the best services for several solutions. Here are the four ways that are affecting to maintain relevance for call accounting and reporting in the world of UC.

Work of call accounting and reporting software

Call accounting and reporting software are built to count costs of calls only: but after some time, they are used to enhance the productivity of the product with its benefits to save the time of managers. With this software important reports sent automatically to emails. You can schedule emails for your important meetings with this software. Moreover, scheduled data helps to review your call data and prepare team meetings easily.

Access from multiple locations and devices is improved

Today, access from multiple locations and devices becomes easy. Call accounting and call reporting software are responsible for this purpose. You can access even your mobile phone. This is crucial to employees that work in the telecom industry.

Call accounting works like software as a service (SaaS) which is related to ASP (application service provider) and delivery models of on-demand computing software. And on-demand computing is one of the famous enterprise models in which resources of computing are available to users according to their needs. The reason behind the development of on-demand is to overcome the general challenges to an enterprise of being capable to meet fluctuating demands powerfully. From this, you can say call accounting and reporting are a perfect choice for an on demand SaaS solution.

The user interface is user-friendly

With only a few clicks from the dashboard, reports are ready to be exported in the file format you select. Today's software with customizable display settings makes the viewing uncomplicated that matters the most. Whatever you decide is most important can go upfront within the dashboard where it is easy to see. Color code graphs to your liking and makes the most relevant metrics stand out and easy to see for your reports and presentations. Your dashboard can be designed in a way that makes you understand and discuss the information at hand.

Billing is simpler

Running reports is easier and faster, therefore, tracking billable talk time is very simple. Grabbing details on any call made allow for more accurate budgeting of departments or clients and leaves a large amount of time freed to develop other opportunities. Moreover, Call Accounting and Reporting Software still keep you on the track of things such as misuse or abuse, especially with long-distance or international calls, and allow the unusual activity to be documented as well. Call accounting and call reporting helps to generate, sending and scheduling bills.

Besides UC call reporting and call accounting is relevant and useful for the development of a business. Today's data-rich, feature-rich, Call Accounting and Reporting software supports visibilities into your communications and still provides great insight into improvements in productivity and reducing costs. Sierra gold California would help you to know more about call accounting and call reporting.

Article Tags: Four Ways, Call Accounting, Call Reporting, Reporting Software

Comparing Effect of CAR-T, ADC, and Double-Antibody for the Treatment of Hematological Tumors

Hematological tumors mainly include myeloma, leukemia (including ALL, CLL, AML, CML) and lymphoma (including HL and NHL). Each year, there are 30,000, 60,000 and 80,000 new patients respectively diagnosed with these three diseases in the United States. Because the blood tumor microenvironment is relatively simple and the B cell resistance is very strong, the blood tumor drug development is relatively easy, and there are many products on the market. The 5-year survival rates of the above three major hematologic tumors were 50%, 70%, and 90% respectively.

 

CAR-T design is getting more and more dazzling.

 

The CAR-T design technology targeted for CD19 and BCMA is the most mature, and now a great many of such projects are being researched. Since the CD19 was first confirmed and two products were already on the market, the introduction of new technologies may bring about more fruitful achievements. Among them, Sloan's so-called armed CAR-T design is complex, including an EGFR fragment as a brake mechanism (cleared with EGFR antibody), a CD28 signaling delivery domain in addition to CD3, and a 4-1BB ligand that activates non-CAR-T bystander T cells. This is called 1928z-41BBL (representing CD19, CD28, CD3, 41BBL, respectively) producing CR of 60% (NHL) and 78% (DLBCL) with good safety and no severe CRS. Unum's CAR-T is a CD16 that binds to an antibody Fc fragment and binds to any antibody, while the antibody is responsible for finding the target tumor cells. They published some biomarker data but no response data. ALLO's allogeneic CD19 CAR-T produces 82% CR and is also safe.

 

BCMA is also very popular. According to incomplete statistics, there are already about 10 companies and research institutes that have entered the clinical BMCA CAR-T. These treatments are very effective, and many still have nearly 100% response to patients, but persistence is a major question that needs to be further addressed. NK cell therapy and CD38 CAR-NK also showed good efficacy in people with CD38 antibody resistance.

 

Double-antibody and ADC are simpler and more practical

 

Although CAR-T is extremely powerful in treating cancer, it is inconvenient to manufacture and use, and the price is high, and the safety control is difficult. Double-antibodies and ADCs targeting the same target are in the traditional drug category, showing sufficient efficacy for several known targets, including those for mAb-resistant patients. For example, the regenerative CD20-C3 double-antibody REGN1979 produced 100% response, 80% CR in R/R FL patients, and Roche's similar drug Mosunetuzumab also produced 38% CR in FL. Amgen's BCMA/CD3 double-antibody AMG420 shows 70% ORR, 40% CR, and a longer half-life AMG701 is under development.

 

Expecting the emergence of new targets

 

Many new target drugs have shown promise in clinical trials at different stages. Karyopharm's small molecule XPO1 covalent inhibitor selinexor produces 30% ORR and 10% CR in patients with DLBCL who are resistant to multiple drugs. XPO1 is responsible for the transport of various proteins, including many tumor suppressor genes, from the nucleus to the cytoplasm. Argenix's CD70 antibody, Cusatuzumab, produced 92% of the ORR in the most refractory hematologic tumor AML, which was acquired by Johnson & Johnson for $500 million. Affimed’s CD30/CD16A Double Antibody, AFM13, produces 44% ORR in patients with CD30-positive lymphoma, and produces 88% ORR and 46% CR in HL when combined with Keytruda. TG Therapeutic's U2 combination of CD20 antibody ublituximab and PI3Kdeta inhibitor umbralisib, together with Keytruda, yields 90% ORR in CLL.

 

Solid tumor TCR therapy

 

On December 5, 2018, the 60th Annual Meeting of the American Association of Hematology held in San Diego was closed. This is the world's largest blood disease academic conference, with a total of 25,000 participants who are all scientists from various countries. One of the biggest highlights at this annual meeting was Gilead's HPV-positive TCR solid tumor cell therapy Kite-439 (obviously from Kite acquisition), which produced 50% ORR in 12 HPV-positive epithelial cell carcinomas. This is a good sign, marking the early use of CAR-T in solid tumors.

 

Summary

 

Many patients die from hematological tumors each year, and the side effects of existing therapies need to be eradicated or lessened. Different killing mechanisms of the same antigen have different curative effects. The effect of CD19 and BCMA are limited. In contrast, CAR-T, double antibody and ADC are very effective. CAR-T is highly effective in patients with recurrent diseases. Although it is more important to find new targets that do not respond to existing target drugs, improving control of confirmed targets also has high value for drug-resistant populations.

Importance Of Regular Health Checkups : You Must Read

Many people, especially in India, believe that we need to visit a doctor only in case of some observed problems. This notion can welcome some more significant diseases like cancer, tuberculosis, etc. to get more complex. That’s why it is imperative to have regular health checkups. There are several benefits associated with regular health checkups, which are ignored by many individuals. In this post, we will explain some of such benefits which will compel you to change your mind if you think regular health checkups are worthless.

  Detecting Diseases at an Earlier Stage

Regular health checkups’ primary objective is to identify any problem at its earliest stage so that the treatment for that can be started early. There are many diseases like cancer whose symptoms are visible only after a considerable amount of time. And in almost every case of such diseases, doctors can treat them well if they are found earlier. Regular health checkups give you an assurance that such critical diseases will be detected and treated in an earlier phase.

 Reducing Overall Healthcare Costs

Many people assume that regular health checkups will be very much costly. But there are many clinics and hospitals which provide full body checkup in Delhi and other parts of India at very nominal rates. Also, the cost of treatment of various diseases is very high if they are detected at later stages. Hence, regular health checkups act as insurance, which will help you in reducing the overall cost of your healthcare.

 Avoiding Many Diseases

Many diseases like heart problems, diabetes, high/low blood pressure, and many more like them can be prevented with the help of regular health checkups. Having regular health checkups gives you an early indication of these diseases in advance. Hence, you can change your lifestyle accordingly at the right time to avoid such problems.

 Keeping Away Stress

Regular health checkups help you in identifying whether your stress level is affecting the functionalities of other organs or not. Hence, you can get a signal at the right time before this stress leads to complex problems. Also, having the satisfaction of good health induces better concentration and less stress. So, regular health checkups help you in avoiding unnecessary stress, which can degrade your mind.

 Identifying the Deficiency of Nutrients

In today’s world, where almost everything is prepared using chemicals, it is very common to have nutrient deficiency. If this deficiency of various nutrients is not treated well, they can form severe problems like Anaemia, lower bone density, and many more like them. Especially in women, deficiency of haemoglobin is very common nowadays. Regular health checkups help you in identifying these problems and treating them within time.

 Nothing is more important in life than having a healthy body and mind. There are several multispeciality hospitals in Delhi and other parts of India which can help you in maintaining good health by getting regular health checkups at reasonable rates. You can go for an annual health checkup or get your full body checkup twice a year.